Turner syndrome (TS), a female-only condition, is one of the most common chromosomal abnormalities worldwide. The most common presenting clinical features of TS are short stature and gonadal dysgenesis. TS is frequently associated with autoimmune conditions including thyroid disease, diabetes mellitus, Celiac disease, and inflammatory bowel disease (IBD). Several studies suggest an increased incidence of IBD in patients with TS. Here we present a case of TS who was diagnosed with Crohn’s disease at the age of 9 years. The patient was on growth hormone treatment for growth retardation. She developed bloody diarrhea and iron deficiency anemia, which subsequently led to the diagnosis of Crohn’s disease. Systematic evaluation of patients with TS, recognition of the association with IBD, and early intervention may improve quality of life, prevent future complications, and may lengthen life expectancy in these patients.